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M94A2390.TXT
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1994-10-25
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Document 2390
DOCN M94A2390
TI Prevalence of HIV among pregnant women identified at prenatal clinics in
Brazil.
DT 9412
AU Oliveira R; Perini N; Pinheiro M; Rodrigues L; Sato P; Antunes C; Loures
L; Department of Health, Brasilia, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):315 (abstract no. PC0189). Unique
Identifier : AIDSLINE ICA10/94370185
AB OBJECTIVES: Indicators (Priority Prevention Indicators, PPIs) for
monitoring National AIDS Programs were developed by GPA/WHO. PPI-5 (HIV
seroprevalence in pregnant women, 15-24 years, attending prenatal
clinics, non-linked) was field tested by the Brasilia Public Health
System (BPHS), in collaboration with the National STD/AIDS Control
Program, Brazil. METHODS: After identifying all BPHS prenatal clinics
(49), the participating Centers were selected by systematic sampling,
based on the number of pregnant women seen at each Center. From each
enrolled Clinic, 75 samples were to be collected (a total of 1500). All
pregnant women in their first clinic visit had their age and parity
recorded. A blood sample was collected in two types of filter paper
(Whatman 4 and Mellita coffee filter); a serum sample was also obtained
to be used as a gold-standard. All Whatman filter paper samples, plus a
random sample of 10% of repeats were tested for HIV using a viral lysate
ELISA (Abbott). All those testing positive plus a 10% random sample of
negatives were re-tested by (1) viral lysate Elisa (Mellita coffee
filter) and (2) recombinant Elisa (serum) plus a confirmatory WB in
those testing positive (serum). RESULTS: A total of 2729 samples were
collected; of those, 1789 (65.6%) were in the required age range.
Preliminary tests (viral lysate Elisa, Whatman 4 samples) were carried
out in 1044 participants; 2 tested positive. The same results were
obtained retesting the positive participants plus a 10% repeat of
negatives, using the Mellita coffee filter (viral lysate Elisa) and
serum samples (recombinant Elisa). The positive results were confirmed
by WB. CONCLUSIONS: The inclusion of PPI-5 in the routine of prenatal
clinics in the BPHS have shown the feasibility of carrying out these
indicators to monitor NAPs. The results obtained should reflect the risk
of HIV infection in the age group, since the prenatal program was
estimated to have a coverage over 90% in the BPHS.
DE Adolescence Adult Ambulatory Care Facilities Brazil/EPIDEMIOLOGY
Enzyme-Linked Immunosorbent Assay Female Human HIV
Infections/DIAGNOSIS/*EPIDEMIOLOGY Pregnancy Pregnancy Complications,
Infectious/DIAGNOSIS/*EPIDEMIOLOGY Prenatal Care Prevalence MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).